The reference site for Abciximab

Abciximab is a platelet aggregation inhibitor mainly used during and after coronary artery procedures like angioplasty to prevent platelets from sticking together and causing thrombus formation within the coronary artery.

WHAT IS Abciximab?

Abciximab is used to lessen the chance of heart attack in people who need percutaneous coronary intervention (PCI), a procedure to open blocked arteries of the heart.
A heart attack may occur when a blood vessel in the heart is blocked by a blood clot. Blood clots can sometimes form during PCI. Abciximab reduces the chance that a harmful clot will form by preventing certain cells in the blood from clumping together.
This medicine is regularly used with aspirin and heparin, which are other medicines used to keep the blood from clotting.

 

Brand Name(s): ReoPro

CAS nº: 143653-53-6

(ab-siks-ih-mab)

Product Info

The sections below will provide you with more specific information and guidelines related to abciximab and its correct use. Please read them carefully.

FDA Information

Abciximab (previously known as c7E3 Fab), is manufactured by Centocor and distributed by Eli Lilly under the trade name ReoPro®.
Abciximab is an FDA approved medication for patients undergoing elective PCI with a stent, or with an acute coronary syndrome (unstable angina or non-ST elevation MI). More than 2 million patients have been treated worldwide with abciximab since its approval by the FDA in 1994.
Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Abciximab is used to lessen the chance of heart attack in people who need percutaneous coronary intervention (PCI), a procedure to open blocked arteries of the heart.
A heart attack may occur when a blood vessel in the heart is blocked by a blood clot. Blood clots can sometimes form during PCI, and abciximab reduces the chance that a harmful clot will form by preventing certain cells in the blood from clumping together.
Abciximab is used with aspirin and heparin, which are other medicines used to keep the blood from clotting.

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Dosage and using this medicine

This medication is given by injection usually 10 to 60 minutes prior to the procedure followed by a continuous infusion into a vein for up to 12 hours.
The dose of abciximab will vary from patient to patient. It is based on your body weight and must be determined by your doctor. The dose will also depend on your medical condition and your response to abciximab, therefore it is paramount that you follow your doctor’s orders.
For injection dosage form:
– For prevention of blood clots during percutaneous coronary intervention (the procedure to open blocked blood vessels):
Adults – Initial dose: 250 micrograms (mcg) per kilogram (kg) of body weight injected 10 to 60 minutes before the procedure. Maintenance dose: 0.125 mcg per kg of body weight per minute (maximum of 10 mcg per minute) by IV for 12 hours.
Children – Use and dose must be determined by your doctor.
– For patients with unstable angina that will undergo percutaneous coronary intervention within 24 hours:
Adults – Initial dose: 250 micrograms (mcg) per kilogram (kg) of body weight injected. Maintenance dose: 10 mcg per minute by IV for 18 to 24 hours, ending 1 hour after the procedure.
Children – Use and dose must be determined by your doctor.

What special precautions should I follow?

BEFORE TAKING ABCIXIMAB:
Be sure to inform your doctor if you have ever had any unusual or allergic reaction to abciximab or murine (mouse) proteins. If you have had abciximab before, you may have developed an allergy to it. Also tell your doctor and pharmacist if you are allergic to any other substances, such as foods, preservatives, or dyes.

Studies on effects in pregnancy have not been done in either humans or animals. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Furthermore, it is not known whether this medicine passes into breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are using this medicine and who wish to breast-feed should discuss this with their doctor.

Additionally, studies on this medicine have been done only in adult patients, and there is no specific information comparing use of abciximab in children with use in other age groups.

Bleeding problems may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults tot the effects of abciximab. It is important that you discuss the use of this medicine with your doctor.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking abciximab, it is especially important that your doctor and pharmacist know if you are taking any of the following: aspirin or anticoagulants (blood thinners such as warfarin [Coumadin®]), cefamandole (Mandol®), cefoperazone (Cefobid®), cefotetan (Cefotan®), clot-dissolving drugs (alteplase [Activase®], streptokinase [Streptase®], or urokinase [Abbokinase®]), dextran, dipyridamole (Persantine®, Aggrenox®) heparin, inflammation or pain medicine, except narcotics, or medicines that prevent platelets from sticking together (clopidogrel [Plavix®], ticlopidine [Ticlid®]). Using any of these medicines together with abciximab may increase the risk of bleeding.

 

What should I do if I forget a dose?

Your doctor should be informed immediately if a dose is missed.

What side effects can this medication cause?

Along with its needed effects, a medicine may cause some unwanted side effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Bleeding; blurred vision; confusion; dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly; sweating; unusual tiredness or weakness.

Less common
Black, tarry stools; bleeding gums; blood in urine or stools; pinpoint red spots on skin; unusual bleeding or bruising.

Rare
Chest pain or discomfort; chills; cough; eye pain; fever; general feeling of illness; headache; pale skin; rapid weight gain; shortness of breath; slow or irregular heartbeat; sneezing; sore throat; swelling of hands, ankles, feet, or lower legs; tightness in chest; tingling of hands or feet; troubled breathing; unusual tiredness; wheezing.
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
More Common
Back pain
Less common
Acid or sour stomach; belching; burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings; changes in vision; delusions; dementia; fear; heartburn; indigestion or stomach discomfort, upset or pain; mood or mental changes; nausea; nervousness; vomiting.
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

 

What storage conditions are needed for this medicine?

Refrigerate abciximab at 36 to 46 degrees F (2 to 8 degrees C). Do not freeze.
Moreover, it is important that you discard any unused portion after the expiration date.

 

In case of an emergency/overdose

In the case of an overdose, call your local poison control center at 1-800-222-1222. However, if the victim has collapsed or is not breathing, call the local emergency services on 911.
Symptoms of overdose may include:
weakness

fatigue

dizziness

dark stool

coffee ground vomit

easy bruising

bleeding under the skin

bleeding from intravenous line

 

Product Images

PICTURES OF {NAME} PILLS

Below you will find images and specific information on the principal types of abciximab that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.
The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: REOPRO®
Strength(s): 10 MG/5 ML
Imprint: Abciximab Reopro
Manufacturer: ELI LILLY & CO.

 

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